Contraindicated (1)pentobarbital will lessen the extent or effect of cariprazine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the formation and elimination of cariprazine's active metabolites. pentobarbital increases effects of ifosfamide by influencing hepatic enzyme CYP2B6 metabolism. Use Caution/Check. Coadministration of ifosfamid... https://deborahr570ept8.jts-blog.com/profile