Limb-threatening or vital limb ischemia (CLI) is manifested by chronic (in excess of two months) ischemic rest agony, ischemic wounds or tissue decline, or gangrene in a single or both of those legs. Ischemic relaxation agony generally happens soon immediately after falling asleep; the individual is awakened by burning agony https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/