To be able to change reaction eqref rxn:four for the remaining ligands which preferentially bind to $ce Cu(I) ,$ have to be additional to the answer. Estrogens raise the liver's ability to manufacture clotting elements. For this reason, individuals getting warfarin need to be monitored for loss of anticoagulant (blood thinning) https://johnm776yju9.wikiexpression.com/user