, ritonavir) or discontinuation of the cytochrome P450 3A4 inducer such as rifampin, carbamazepine, and phenytoin, might cause an increase in codeine plasma concentrations with subsequently higher metabolism by cytochrome P450 2D6, causing bigger morphine amounts, which could increase or prolong adverse reactions and may induce possibly deadly respiratory depression. https://paxtonauowi.blazingblog.com/32344019/5-simple-statements-about-akorn-codeine-explained